Research Solutions
Crystec’s mSAS® (modified Supercritical Anti-Solvent) technology is a versatile platform that offers a range of strategies to overcome product development challenges and optimise performance. How can Crystec help you to achieve your product development goals?
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Improving Dissolution
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optimised inhaled therapies
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Enhancing Stability
Chemical and physical stability is vital to ensure that therapeutics can be manufactured, stored, transported and administered to patients without a loss of efficacy or safety. mSAS® enables manufacture of highly pure, residue-free drug particles, capable of resisting moisture, and able to withstand higher temperatures.
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Simplified Formulations
Formulation is often a complex, multi-step process, adding considerable time and cost to development. The mSAS® process involves a single step, and enables design of particles which contain all the components required for a medicine to perform, reducing the need for downstream processing.
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Biomolecule Processing
Biotherapeutics such as peptides, proteins, antibodies and oligonucleotides are often delicate and easily damaged. mSAS® provides a gentle way to process biomolecules as free-flowing powders, retaining high levels of activity, reducing cold chain and enabling easier reconstitution.
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Natural Products
Natural products are often highly complex and conventional approaches to their extraction, purification and formulation can be inefficient and often result in a poor-quality product. mSAS® simplifies production of natural products, allowing fine tuning of the components of a medicine and improvements in quality and consistency.
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Green Manufacturing
Improvements in human health should not come at a cost to the planet, yet traditional approaches to medicine manufacturing carry a high environmental burden. mSAS® enables the production of medicines with lower waste, reduced emissions, using less solvent, and greatly improved energy efficiency.
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Intellectual Property
Innovation in medicine development often requires robust protection of intellectual property (IP). The mSAS® process provides numerous opportunities to enhance IP, whether through novel solid-state forms, improved formulations, or new routes of delivery.